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Created with Fabric.js 1.4.5 Prevacid (Lansoprazole) Prevacid (Lansoprazole) Kevan GovindGonzalez p.5 Pharmacokinetics: a)Absorption- absorption is rapid;Tmax is 1.7 hours or 1hr 42min. Cmax is 15-60mg; Bioavailability is 80%. b)Distribution- Over the concentration range 0.05 to 5 mcg/mL, protein binding is 97%c)Metabolism- the drug is metabolized in the liver; metabolites includehydroxylated sulfonyl and sulfone derivatives d)Elimination- Metabolites excrete using significant biliary action; this means it is excreted through bile activation in liver; Half Life is an average 1.9-2.9 hours Mechanism of Action Proton Pump Inhibitor- Inhibit the action of the gastric proton pump, thereby reducing gastric acid production. Binds to H+/K+-exchanging ATPase (proton pump) in gastric parietal cells, resulting in suppression of basal and stimulated acid secretion Special Populations The Elderly Those With Hepatic Function Impairment Clinical Studies A study of 284 patients with endoscopically documented duodenal ulcer, the percentage of patients healed after two and four weeks was significantly higher with all doses ofLansoprazole than with placebo Common Dosage 15 mg Route of Administration By Mouth (PO) Cost: $.85 per Capsule Short-Term Duodenal Ulcer Treatment, H. Pylori Eradication, and Maintenance of Healed Duodenal Ulcer Indications/Usage 08/12/05-07/20/10 Contraindications Patients who are Hypersensitive tothe Active IngredientsErlotinibNelfinavirRilpivirine Gastric Malignancy, Clostridium difficile Associated Diarrhea, Bone Fracture, Hypomagnesemia, Concomitant Use of Lansoprazole with Methotrexate Warnings/Precautions
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