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Created with Fabric.js 1.4.5 Patients enrolled on Methotrexate treatment: 49 32 out of 49 patients experienced a decrease in serum uric acid levelsPatients enrolled as Controls: 40 18 out of 40 patients experienced a decrease in serum uric acid levels Uric Acid Uric Acid SJC28 at 18 Months Comparing SJC28 at 18 months between patientswho experienced a decrease in uric acid on Methotrexate vs. those that did not.p = 0.035 Comparing DAS28 at 18 Months between patientswho experienced a decrease in uric acid onMethotrexate vs. the Control patient cohort.p = 0.042 Responders 3.26 2.37 Methotrexate | Uric Acid Normal Range for Uric Acid: Male: 238 - 506 umol/L Female: 149 - 446 umol/L Patients Enrolled on Methotrexate Treatment: Pre-Treatment UA: 300 umol/L Post-Treatment UA: 273 umol/L{p = 0.035}Patients Enrolled as Controls: Baseline UA: 280 umol/L Follow-Up UA: 282 umol/L{p = 0.448} Patients who experienced a decrease in uric acid levels related to Methotrexate therapy showed a better clinical outcome at 18 months following diagnosis. compared to control patients who were not treated with Methotrexate. DAS28 at 18 Months Controls MTX - Uric Acid Patients who experienced a decrease in uric acid levels on Methotrexate showed a better clinical outcome at 18 months following diagnosis. compared to patients who did NOT experience a decrease inuric acid. Change in Uric Acid -27 umol/L +2 umol/L (MTX) (Control) Decrease in Uric Acid on Methotrexate Therapy vs. Controls p = 0.042 4.47 0.89
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