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Created with Fabric.js 1.4.5 Some women suffer from infertility because the mitochondria in theireggs are defective. In addition, some children are born with diseases associated with broken mitochondria which are inherited directly from a baby's mother. Three-Parent Babies Why? How? To cure infertility and to prevent children from being born with mitochondrial diseases, fertility specialists are proposing to implement two procedures. 1.Maternal Spindle Transfer 2.Pro-Nuclear Transfer Genes are taken from the nucleus in the eggof the prospective mother whose mitochondria are defective and inplanted into a donor egg with safe mitochondria and have had there nuclear genes removed. The reconstituted egg is then fertilized. In pro-nuclear transfer involves taking nuclear material from a fertilized egg before the nuclei of the sperm and egg have fused and installing it into a donated enucleated egg. Nucleus Nucleus Sperm Unhealthy Mitochondria Unhealthy Mitochondria Healthy Mitochondria Healthy Mitochondria X X Mother's Egg Donor's Egg Donor Egg Donor Egg Donor's Fertalized Egg Donor's Fertalized Egg Mother's nuclearmaterial removed and kept Donor nuclear material removed and destroyed Mother's nucleus placed inside donoregg and fertilization Parent's nuclearmaterial removed and kept Donor nuclear material removed and destroyed Parent's nuclear material placed inside donor egg
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