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Created with Fabric.js 1.4.5 Too much glutamate which is toxic to nerve cells. The immune system can attack normal alleles. Also, mishandled proteins in nerve cells can accumulate in abnormal forms. All of these are mutations which result in nerve cells dying. Treated/Diagnosed Cause/Inherited Defention A nervous system disease that causes muscle weakness and impacts physical functions. Generally affects the nervous system the most. Lou Gehrig's Disease Amyotrophic Lateral Sclerosis ALS causes nerve cells to gradually break down and die. As a result, your muscles will become weaker and weaker till they can't work at all. Symptoms ALS is autosomal dominant. Only one mutated copy of the gene is needed. Also, one parent carrier gives the offspring a chance of getting it. ALS is sporadic (not sexed linked). ALS is found on chromosome 2/8 and variations on chromosome 9p. It is not ethnictity specif. It is non disjunction. Tests are done to rule out other diseases. Such as, electromyogram, nerve conduct tests, magnetic resonance, blood and urine tests, spinal tab and muscle biopsy. Genetic counseling is an option. Gene therapy is not an option. The only drug approved by the FDA for ALS is riluzole. It reduces level of glutamate to slow down disease. Common/Intresting It is common with more men than women before the age of 65. After reaching the age of 70 it disappears after the age of 70. It's a 5-10% inherit it. People with familial ALS have these kids with a 50-50% chance of getting it. Lou Gehrig's Disease is called this because a famous baseball player was diagnosed with it. ALS is not contagious. By Eli Bergner
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