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Created with Fabric.js 1.4.5 When it inhibits cyclooxygenase, also known as COX-2, prostaglandin production stops When it is ingested you do not feel pain and your muscles don't swell Advil is lipid soluble and is therefore able to cross the cell membrane Cyclooxygenase COX-2 COX-2 is responsible for the productionof prostagladins Advil treats headaches, minor arthritis and otherjoint pain,muscle aches, backaches, menstrual pain, and aches and pains of the common cold. Advil is a drugthat non-competitive inhibitor of cyclooxygenasewhich is the enzyme responsible for pain. COX-2 can be foundanywhere in your bodybecause pain can befelt anywhere Prostaglandins Prostaglandins cause inflammation and pain. They are ligands that signal pain to neurons and the brain. They ligate trans-membraneproteins which are G-Coupled Protein Receptors http://c431376.r76.cf2.rackcdn.com/43269/fphar-04-00034-HTML/image_m/fphar-04-00034-g001.jpg http://www.nature.com/nrc/journal/v1/n1/images/nrc1001-011a-f4.gif http://solutions-recovery.com/solutions_blog/wp-content/uploads/2012/12/cox-2-inhibitors.png http://e-internetbusiness.com/wp-content/uploads/2009/05/advil.jpg Cyclooxygenase, COX-2, is produced by Arachidonic Acid http://images.slideplayer.us/2/763673/slides/slide_9.jpg http://3.bp.blogspot.com/-UPuvNOUQgH4/TdtgrZE0HHI/AAAAAAAAJNA/_GDt7BeYZY0/s1600/cox.jpg http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081099/ Advil http://www.fasebj.org/content/12/12/1063.full By Colleen Kelch and Veronica Lane http://scienceunraveld.com
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